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Dunathan stereoelectronic hypothesis : ウィキペディア英語版 | Dunathan stereoelectronic hypothesis
Dunathan stereoelectronic hypothesis is a concept in chemistry to explain the stereospecefic cleavage of bonds using pyridoxal phosphate. This occurs because stereoelectronic effects controls the actions of the enzyme. ==History== Before the correlation between fold type and reaction correlation of proteins were understood, Harmon C. Dunathan, a chemist at Haverford College〔http://www.haverford.edu/chem/mackay/ColinWeb/MacKay_Web.html〕 proposed that the bond that is cleaved using pyridoxal is perpendicular to the system.〔http://chemgroups.ucdavis.edu/~toney/Stereoelectronic.html〕 Though an important concept in bioorganic chemistry, it is now known that enzyme conformations play a critical role in the final chemical reaction.
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